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FIGS. 16A and 16B are graphs that show the mean and median tumor growth curves by treatment group: isotype control mIgG1, anti-PD-1 mg1, and/or anti-ICOS.4 mIgG1 ("ICOS.4 mg1") antibodies. Mice were treated with isotype control mG1, ICOS.1 mg1 D265A, ICOS.4 mg1, ICOS.4 hg1, or ICOS.4 mg2a on days 7, 10, and 14 post-Sa1N cell implantation. In one aspect, the isolated antibody has reduced antibody-dependent cell-mediated cytotoxicity (ADCC) activity compared to an IgG1 control antibody. In another aspect, an anti-ICOS antibody is provided for administration (or co-administration with another antibody, e.g., an anti-PD-1 antibody, an anti-PD-L1 antibody, and/or an anti-CTLA-4 antibody) according to the methods described herein. In another aspect, the composition further comprises a soluble neutral-active hyaluronidase glycoprotein. 13. A composition comprising the antibody of claim 1 and a pharmaceutically acceptable carrier. 14. The composition of claim 13, further comprising an additional therapeutic agent, wherein the additional therapeutic agent is an anti-cancer therapeutic agent, an immunostimulatory therapeutic agent, a chemotherapeutic agent, a radiotherapeutic agent, an immunotherapeutic agent, and/or an immunogenic therapeutic agent. Therapeutic agents such as monoclonal antibodies that target this PD-1/PD-L1 interaction, such as nivolumab (Opdivo.RTM.), can block the PD-1/PD-L1 binding to increase the body's immune response against tumor cells.

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Elizabeth Neff (May 22, 2004). "Janet's publicity prompts lawsuit". In May 2013, a 3-choose panel of the U.S. On December 12, 2018, U.S. Machado, Kenan (7 December 2010). "Al Jazeera English to Broadcast in India". Roland S. Martin (February 8, 2010). "Nothing erroneous with Tebow Super Bowl ad". Brian J. Pedersen (February 2, 2009). "Comcast provides $10 credit score to Tucson prospects who observed Super Bowl". Josh Grossberg (February 5, 2009). "Feds Planning Super Bowl Porn Probe". David Bauder (February 6, 2012). "Censors MIA on M.I.A.'s finger flip". Cherner Reid (June 29, 2012). "Supreme Court is not going to hear Janet Jackson Super Bowl case". John Hudson (February 6, 2012). "M.I.A.'s Middle Finger Could Be Expensive for NBC". John Eggerton (September 4, 2006). "Behind the Cultural Clean-Up". Ali, Yashar (September 7, 2018). "Exclusive: Les Moonves Was Obsessed With Ruining Janet Jackson's Career, Sources Say". He was re-elected in 2014 and 2018 right after profitable primaries from progressive challengers. Wigler, Josh Rae, Brandon (March 6, 2014). "'Captain America': 9 Secrets From 'The Winter Soldier' Set".

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