In other embodiments, the term "nucleotide analogs" refers to nucleotides having modified base moieties. The term "design" or "oligomer design" or "ASO Sequence" as used herein refers to a pattern of nucleotides (e.g., DNA) and nucleotide analogs (e.g., LNA) in a given sequence. In yet other embodiments, polynucleotides comprise a nucleotide sequence encoding a protein or polypeptide. In some embodiments, the oligomer is a single stranded molecule, and does not comprise short regions of, for example, at least 3, 4 or 5 contiguous nucleotides, which are complementary to equivalent regions within the same oligomer (i.e. duplexes)--in this regard, the oligomer is not (essentially) double stranded. The term "expression" as used herein refers to a process by which a polynucleotide produces a gene product, for example, a RNA or a polypeptide. The term "polynucleotide" as used herein refers to two or more nucleotides linked in sequence. It includes, without limitation, transcription of the polynucleotide into messenger RNA (mRNA) and the translation of an mRNA into a polypeptide.

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