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A "fusion" or "fusion" protein comprises a first amino acid sequence linked in frame to a second amino acid sequence with which it is not naturally linked in nature. In one embodiment, the citrate buffer comprises anhydrous citric acid and anhydrous sodium citrate. In one embodiment, the anti-PD-L1 antibody is MEDI4736 (durvalumab). It is to be noted that the term "a" or "an" entity refers to one or more of that entity; for example, "a nucleotide sequence," is understood to represent one or more nucleotide sequences. For example, 80.11, 80.12, 80.13, and 80.14 are rounded down to 80.1, while 80.15, 80.16, 80.17, 80.18, and 80.19 are rounded up to 80.2. It also is noted that the length value will always be an integer. For example, the antigen binding portions can be derived from any of the antibodies or antibody variants known in the art. Under physiological conditions, the PAS sequence stretch forms a random coil conformation and thereby can mediate an increased in vivo and/or in vitro stability to the IL2 polypeptide.





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