Peter has enjoyed a decidedly more low-key life than his cousins Prince William and Prince Harry that started with his mother Princess Anne's decision not to give him and his younger sister Zara, 38, now married to Mike Tindall, a royal titles. ‘The two of them talked off and on all through the night,’ Gill remembers, Richard speaking quietly to Hughes and feigning an interest in his life in order to establish a rapport between them. ’ Gill went on, using his name purposely in the hope of strengthening the bond she sensed he now imagined to exist between them. From the floor, Gill turned her head and tried to calm her father. The Phillipses lived in Hong Kong after Peter moved jobs within the Royal Bank of Scotland to head their sponsorship activities in the region. The Queen's eldest grandson Peter Phillips and wife Autumn have separated following 12 years of marriage, the couple announced today.

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An "inhibitor" or "antagonist" refers to an agent that inhibits, decreases, or reduces one or more activities of a molecule in a PI3K/AKT/mTOR pathway including, without limitation, a PI3K, an Aid, or an mTOR (or mTORC1, mTORC2 complex). An "activator," or "agonist" refers to an agent that promotes, increases, or induces one or more activities of a molecule in a PI3K/AKT/mTOR pathway including, without limitation, a molecule that inhibits one or more activities of a PI3K, an Akt, or an mTOR (or mTORC1, mTORC2 complex). TOR acts through the canonical PI3K pathway via 2 distinct complexes, each characterized by different binding partners that confer distinct activities. In particular embodiment, the inhibitor may inhibit a class of molecules have the same or substantially similar activities (a pan-inhibitor) or may specifically inhibit a molecule's activity (a selective or specific inhibitor). In particular embodiments, conditions appropriate for T cell culture include an appropriate media (e.g., Minimal Essential Media or RPMI Media 1640 or, X-vivo 15, (Lonza)) and one or more factors necessary for proliferation and viability including, but not limited to serum (e.g., fetal bovine or human serum), interleukin-2 (IL-2), insulin, IFN-.gamma., IL-4, IL-7, IL-21, GM-CSF, IL-10, IL-12, IL-15, TGF.beta., and TNF-.alpha. In particular embodiments, T cells may be contacted or treated or cultured with one or more modulators of a PI3K/AKT/mTOR pathway for at least 12 hours, 18 hours, at least 1, 2, 3, 4, 5, 6, or 7 days, at least 2 weeks, at least 1, 2, 3, 4, 5, or 6 months or more with 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 or more rounds of expansion.

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