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In the context the term "conjugate" is intended to indicate a heterogeneous molecule formed by the covalent or non-covalent attachment ("conjugation") of the oligomer as described herein to one or more non-nucleotide, or non-polynucleotide moieties. Conjugation (to a conjugate moiety) can enhance the activity, cellular distribution or cellular uptake of the oligomer of the invention. In certain other embodiments, a therapeutic molecule of the invention comprises one or more binding sites derived from a non-immunoglobulin binding molecule. The therapeutic molecules comprising nucleotide sequences can then be subject to the methods of the present invention described elsewhere herein. Adhesion molecules are membrane-bound proteins that allow cells to interact with one another. Conservation of proteins with PEST sequences among different species supports their functional significance. In one embodiment, random therapeutic molecules comprising nucleotide sequences (e.g., oligomers) targeting certain regions of pre-mRNA or mRNA encoding MAPT, BASP1, or APP are prepared to test their toxicities. In other embodiments, the molecules selected according to the present methods are therapeutic molecules.

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