International Search Report and Written Opinion for International Application No. PCT/US2015/027539, gone out with Nov. 2, 2015, 6 pages. International Preliminary Report on Patentability for International Application No. PCT/US2015/027539, dated Oct. 25, 2016, My Usa Sex 6 pages. International Preliminary Report on Patentability for International Application No. PCT/US2015/034515, gone out with Dec. 5, 2016, 10 web pages. International Preliminary Report on Patentability for International Application No. PCT/US2015/027518, dated Oct. 25, 2016, 6 pages. International Preliminary Report on Patentability for International Application No. PCT/US2015/064269, dated Jun. 22, 2017, 6 web pages. International Search Report and also Written Opinion for International Application No. PCT/US2015/064269, dated Feb. 23, 2016, 9 pages. International Search Report and also Written Opinion for International Application No. PCT/US2015/041722, dated Jan. 6, 2016, 11 webpages. International Application No. PCT/US2015/041722, International Preliminary Report on Patentability old Jan. 24, 2017, 7 web pages. International Preliminary Report on Patentability for International Application No. PCT/US2015/027510, dated Oct. 25, 2016, 6 pages. Gattinoni, L., et al., "Adoptive immunotherapy for cancer: building on success." Nat Rev Immunol (2006 ); 6( 5 ): 383-393, 25 web pages.



Malim et al., "Immunodeficiency virus rev trans-activator regulates the phrase of the virus-like governing genetics", Nature (1988 ); 335: 181-183. presented through candidate. Naldini, L. et cetera, "In vivo gene shipment and dependable transduction of nondividing tissues through a lentiviral angle", Science (1996 ); 272( 5259 ): 263-267. cited through applicant. Imren, S. et al., "High-level beta-globin articulation and chosen intragenic combination after lentiviral transduction of individual wire blood stalk cells", J Clin Invest (2004 ); 114( 7 ): 953-962. presented through applicant. Koldej, R.M., et al., "Comparison of Insulators and Promoters for Expression of the Wiskott-Aldrich Syndrome Protein Using Lentiviral Vectors" Human Gene Therapy Clinical Development (2013 ); 24: 77-85. mentioned by candidate. Kim, Yang-Gyun, et cetera "Hybrid restriction chemicals: zinc hands combinations to Fok I bosom domain name." Proceedings of the National Academy of Sciences (1996 ); 93.3: 1156-1160. mentioned by candidate. Proceedings of the National Academy of Sciences (1997 ); 94.11: 5525-5530. pointed out by applicant. Proceedings of the National Academy of Sciences (1993 ); 90.14: my usa sex 6444-6448. mentioned through applicant.



Milone, M. et cetera, "Chimeric receptors having CD137 indicator transduction domain names mediate boosted survival of T cells and also increased antileukemic efficiency in vivo", my usa sex Molecular Therapy (2009 ); 17( 8 ):1453 -1464. pointed out by applicant. Liu, Lin, et cetera, "Adoptive T-cell treatment of B-cell malignancies: Physical as well as standard chimeric antigen receptors." Cancer Letters (2012 ); 316( 1 ): 1-5. pointed out through applicant. Nature Biotechnology (2007 ); 25.12: 1477-1482. pointed out through candidate. Nature Reviews Drug Discovery (2009 ); 8.8: 627-644. mentioned by candidate. 9: 1766-1780. pointed out by applicant. Miller, A.D., "Human genetics treatment matures." Nature (1992 ); 357: 455-460. mentioned through applicant. Huang and Yen, "Role of the hepatitis B infection posttranscriptional regulatory component in export of intronless records", Cellular as well as molecular Biology (1995 ); 15( 7 ): 3864-3869. pointed out through candidate. Maldarelli et al., "Identification of posttranscriptionally active inhibitory sequences in human immunodeficiency virus style 1 RNA: unfamiliar degree of genetics policy", Journal of Virology (1991 ); 65( 11 ): 5732-5743. presented by applicant.





Landau and Littman. "Packaging system for swift production of murine leukemia infection vectors along with changeable tropism." Journal of Virology (1992 ); 66.8: 5110-5113. presented by candidate. Cell (1984 ); 36.4: 897-906. cited through applicant. Koch-Nolte, F., "Single domain antibodies coming from llama successfully and also primarily obstruct T tissue ecto-ADP-ribosyltransferase ART2.2 in vivo", FASEB J (2007 ); 21( 13 ):3490 -3498. cited by applicant. Kay, M. A., "Adenoviral Vectors for Hepatic Gene Transfer in Animals." Chest (1997 ); 111: 138S-142S. pointed out through applicant. Gallop, Mark A., et cetera. The EMBO Journal (1992 ); 11.11: 3897-3904. mentioned by applicant. Annual Review of Immunology (2003 ); 21.1: 231-264. mentioned through applicant. Holt, L. et cetera, "Domain antitoxins: healthy proteins for therapy", Trends in Biotechnology (2003 ); 21( 11 ): 484-490. mentioned through applicant. Nature medicine 9.1 (2003 ): 129-134. presented by applicant. Giannoni, F., et cetera, "Allelic Exclusion as well as Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells." Molecular Therapy (2013 ); 21( 5 ): 1044-1054. presented by candidate. Lovelock as well as Bishop, "Prevention of freezing harm to living cells by dimethyl sulphoxide", Nature (1959 ); 183( 4672 ): 1394-1395. pointed out by applicant. 1975-1981. cited by applicant. 8125-8148. cited by candidate.