Examples of anti-CTLA-4 antibodies include, but are not limited to, those described in U.S. Popular ones such as Keno & Roll The Dice are available to use as both apps & bots. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works. Examples of PD-1/PD-L1 inhibitors include, but are not limited to, those described in U.S. In one embodiment, the checkpoint inhibitor is a PD-1/PD-L1 inhibitor. In one embodiment, the anti-PD-L2 antibody is rHIgM12B7A. In one embodiment, the anti-GITR antibody is TRX518. In one embodiment, the anti-PD-1 antibody is nivolumab (also known as ONO-4538, BMS-936558, or MDX1106) or pembrolizumab (also known as MK-3475, SCH 900475, or lambrolizumab). In one embodiment, the checkpoint inhibitor is a CD137 agonist. In one embodiment, the PD-L2 inhibitor is an anti-PD-L2 antibody. In one embodiment, the checkpoint inhibitor is an IDO inhibitor. In another embodiment, the IDO inhibitor is indoximod.





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In some embodiments, the methods provided herein are used to treat drug resistant leukemias, such as chronic myelogenous leukemia (CML). As those of ordinary skill in the art are aware, the treatment of cancer is often based on the stages and mechanism of the disease. In certain embodiments, a lyophilized formulation of Compound 1 provided herein is administered in combination with carboplatin and/or taxotere, or in combination with carboplatin, pacilitaxel and/or thoracic radiotherapy to patients with non-small cell lung cancer. In certain embodiments, a lyophilized formulation of Compound 1 provided herein is administered to patients with scleroderma or cutaneous vasculitis in combination with celebrex, etoposide, cyclophosphamide, docetaxel, apecitabine, IFN, tamoxifen, IL-2, GM-CSF, or a combination thereof. Embodiments provided herein may be more fully understood by reference to the following examples. Because subjects with cancer have heterogeneous clinical manifestations and varying clinical outcomes, the treatment given to a patient may vary, depending on his/her prognosis. The skilled clinician will be able to readily determine without undue experimentation specific secondary agents, types of surgery, and types of non-drug based standard therapy that can be effectively used to treat an individual subject with cancer.



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