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TNF receptor superfamily described supra (e.g., a soluble TNF.alpha. In one exemplary embodiment, the binding site of the receptor-binding portion of a ligand is derived from a ligand belonging to the TNF ligand superfamily described supra (e.g., CD40L). Exemplary cytokines include the interleukins (e.g. IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-11, IL-12, IL-13, and IL-18), the colony stimulating factors (CSFs) (e.g. granulocyte CSF (G-CSF), granulocyte-macrophage CSF (GM-CSF), and monocyte macrophage CSF (M-CSF)), tumor necrosis factor (TNF) alpha and beta, cytotoxic T lymphocyte antigen 4 (CTLA-4), and interferons such as interferon-.alpha., .beta., or .gamma. Glial Cell-Derived Neurotrophic Factor (GDNF) receptor family (e.g., GFR.alpha.3), a receptor of the G-protein coupled receptor (GPCR) superfamily, a receptor of the Tyrosine Kinase (TK) receptor superfamily, a receptor of the Ligand-Gated (LG) superfamily, a receptor of the chemokine receptor superfamily, IL-1/Toll-like Receptor (TLR) superfamily, and a cytokine receptor superfamily. Pat. Nos. 5,227,158 and 6,099,841), neurotrophic factors such as bone-derived neurotrophic factor (BDNF), glial cell derived neurotrophic factor ligands (e.g., GDNF, neuturin, artemin, and persephin), neurotrophin-3, -4, -5, or -6 (NT-3, NT-4, NT-5, or NT-6), or a nerve growth factor such as NGF-.beta.



Pat. Nos. 6,403,764 and 6,506,874); Erythropoietin (EPO); Thrombopoeitin (TPO; stem-cell factor (SCF), thrombopoietin (TPO, c-Mpl ligand), and the Wnt polypeptides (U.S. Other examples of therapeutic molecules not derived from antibody molecules include receptor binding sites and ligand binding sites which are discussed in more detail infra. The higher the rank of the website the more traffic will be generated. In particular, they will tell you how you can download Android Market on your tablet as it doesn't come pre-installed. I am petrified that in the future (maybe after marriage and kids) he will realize that he’s not bisexual, he’s gay, and that he has locked himself into a life that isn’t right. Right now, there are just a handful of players experimenting with the medium. I just got out of a long-term relationship and I'm still recovering from that, so I don't want a boyfriend right now, but I'm still craving physical contact and sex, so he's definitely fulfilling that requirement.



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Various adhesion proteins, including leukocyte homing receptors and cellular adhesion molecules, or receptor binding portions thereof, can be incorporated in a fusion protein of the invention as therapeutic molecules, binding sites and/or domains. TGF-alpha and TGF-beta (WO 90/14359), osteoinductive factors including bone morphogenetic protein (BMP); insulin-like growth factors-I and -II (IGF-I and IGF-II; U.S. Growth factors or their receptors (or receptor binding or ligand binding portions thereof) may be incorporated in the fusion proteins of the invention. In other aspects, the therapeutic molecule of the invention comprises antigen binding sites, or portions thereof, derived from modified forms of antibodies. In another embodiment, a therapeutic molecule of the invention comprises a binding site from an Anticalin.RTM. In other aspects, a molecule of the invention comprises a ligand binding site of a receptor and/or a receptor binding portion of a ligand. In other embodiments, the binding site or domain of the receptor-binding portion of a ligand is derived from a ligand bound by an antibody or antibody variant described supra. In certain embodiments, the ligand binding portion of a receptor is derived from a receptor selected from a receptor of the Immunoglobulin (Ig) superfamily (e.g., a soluble T-cell receptor, e.g., mTCR.RTM. Pat. No. 5,453,491), IL10 receptor, IFN.gamma.