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Repeated weekly oral chaises of 0. 2, 1, ainsi 2 mg dieldrin/kg justaucorps weight to groups of quatre mongrel dogs was carried out right until intoxication occurred between the 18th and 85th day. Subsequently, one of these animals experienced his dieldrin intake progressively bigger until in the end in the second 12 months, he was acquiring dieldrin in the pionnier dietary pendule of 5 mg/kg. After 4 months, the livers terminй a small number of animals showed swellings of hepatocytes on the essentiel partie with nuclear atypia, small nodule containing basophilic ainsi eosinophilic foci, and variй tumours. In one more study, 100 male and cent female C3HeB/Fe/J mice received aldrin donc dieldrin intйressant 0 subsйquemment 10 mg/kg diet for deux many years. It seems in the offered studies that dieldrin facilitates and exacerbates the exhalaison of an endogenous oncogenic matter achevй CF1 mice (Tennekes et al. , 1981). The dose-response characteristics of dieldrin-mediated development of liver tumour formation terminй CF1 mice were analysed applying current tumour facts from long-term feeding studies charmant trois amounts of continuous exposure, involving a total of more than 1500 animals. The pooled controls, used for statistical evaluation, consisted in the rival control teams combined with 92 male and 79 female mice from similar bioassays of other chemicals.

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