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Spatial learning and memory can be assessed based on a Morris Water Maze test as shown in Morris J. Neurosci. For Morris Water Maze (MWM), a repeated MWM ANOVA is used to analyze the acquisition phase and a one-way ANOVA followed by Dunnett's post-hoc for probe trial analyses. An immunoglobulin constant region or a portion thereof for producing the fusion protein of the present disclosure may be obtained from a number of different sources. In one embodiment, the immunoglobulin constant region or a portion thereof comprises CH2 domain, CH3 domain, and a hinge region, i.e., an Fc region or an FcRn binding partner. EC in IL2 binding. Human IL2 exerts its biological effects via signaling through its receptor system, IL2R. IL2 and its receptor (IL2R) are required for T-cell proliferation and other fundamental functions which are crucial of the immune response. It has been shown that Fc.gamma.RI, Fc.gamma.RII, and Fc.gamma.RIII, which mediate various effector functions will not bind to IgG1 when such mutations have been introduced.

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