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The term "oligomer" in the context of the present invention, refers to a molecule formed by covalent linkage of two or more nucleotides (i.e., an oligonucleotide). Sequence score for each oligomer was calculated by inserting appropriate numbers in the formula: ((number of C nucleotides or the analogs-number of G nucleotides)/nucleotide length (number) in the oligomer). The oligomer comprises a contiguous nucleotide sequence of from about 10 to about 50, such as 10-20, 16-20, 10-30, 10-35, 10-40, or 10-45 nucleotides in length. FIG. 3: Correlation analysis of sequence score vs. FIG. 6: shows Tau protein reduction by exemplary antisense oligonucleotides. FIG. 5: shows in vivo tolerability of exemplary antisense oligonucleotides. FIG. 5 lists the ASO identification number, ASO sequence, SEQ ID Number, target start and end positions on the MAPT pre-mRNA sequence, in vivo acute tolerability score (as discussed in Example 6 below) and the percent of brain MAPT mRNA remaining after administration (as also discussed in Example 6 below). FIG. 6 lists the SEQ ID number, oligomer name, ASO identification number, ASO sequence, target start and end positions on the MAPT pre-mRNA sequence, target start on the mature mRNA sequence and normalized Tau/Tuj-1 and Tuj-1 immunocytochemistry values (as discussed in Example 7 below).

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