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In other embodiments, a therapeutic molecule of the invention comprises a binding site from a single chain binding molecule (e.g., a single chain variable region or scFv). Single chain antibodies are formed by linking the heavy and light chain fragments of the Fv region via an amino acid bridge, resulting in a single chain antibody. In certain embodiments, the nucleotide sequence binds or hybridizes to a nucleic acid sequence (DNA or RNA, e.g., pre-mRNA or mRNA) encoding one or more polypeptides disclosed above in Sections III.A., III.B., and III.C.1-III.C.5. In certain embodiments, the therapeutic molecules (e.g., oligomers) target a pre-mRNA encoding an amyloid precursor protein. In one embodiment, random therapeutic molecules comprising nucleotide sequences (e.g., oligomers) targeting certain regions of pre-mRNA or mRNA encoding MAPT, BASP1, or APP are prepared to test their toxicities. In another embodiment, the nucleotide sequence for the present disclosure is RNA. In other embodiments, the internucleoside linkages within the contiguous nucleotide sequence are phosphorothioate or boranophosphate internucleoside linkages.

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But through the sea of people are Kelli Saint, Shannon Saint and Lola who are holding "No Shannon, No Peace" signs and have their own independent microphones. RR: I noticed Shannon doesn't have his Burger King crown with him tonight! RR: They put on a stellar match, but are now joining forces because of their opponents! 4 training sessions a day are also required, of which one has to be stretching/yoga. You will get home and she will post it on the group chat and one committee member will say ‘No, too formal,’ or ‘No, blue is not your colour,’ and they will all pile in and that dress will never be seen again. Victoria, pictured in her 20s, admits she used to be more eager to get male attention when she was younger (left). Although he only finished fourth, his performance attracted the attention of agent Nigel Klarfeld of Gagged and Bound Comedy Limited.

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