Unlike a Phase III clinical trial, there is no placebo group in an open-label study. In ASPIRE, there were 27 percent fewer women who acquired HIV in the group assigned to use the dapivirine ring than in the group who used a placebo ring with no active drug. The monthly ring tested in ASPIRE and The Ring Study, and offered to women in the HOPE and DREAM studies, contains an ARV drug, dapivirine, as a way to provide women potentially longer-acting protection against HIV. New results from exploratory analyses of data from ASPIRE reported today at The International Conference on AIDS (AIDS 2016) in Durban suggest even higher levels of protection can be achieved with regular and consistent use. It will be released June 2 at a Northwestern policy conference in Washington, D.C. MTN-034/IPM 045 will help to better understand the factors that may have contributed to the ring not being effective among those ages 18-21 in ASPIRE. Toward this end, MTN is planning a study (MTN-034/IPM 045) that will evaluate how adolescent girls and young women use the monthly dapivirine vaginal ring and Truvada as daily PrEP, and their preferences for either or both approaches.

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Unlike a Phase III clinical trial, there is no placebo group in an open-label study. In ASPIRE, there were 27 percent fewer women who acquired HIV in the group assigned to use the dapivirine ring than in the group who used a placebo ring with no active drug. The monthly ring tested in ASPIRE and The Ring Study, and offered to women in the HOPE and DREAM studies, contains an ARV drug, dapivirine, as a way to provide women potentially longer-acting protection against HIV. New results from exploratory analyses of data from ASPIRE reported today at The International Conference on AIDS (AIDS 2016) in Durban suggest even higher levels of protection can be achieved with regular and consistent use. It will be released June 2 at a Northwestern policy conference in Washington, D.C. MTN-034/IPM 045 will help to better understand the factors that may have contributed to the ring not being effective among those ages 18-21 in ASPIRE. Toward this end, MTN is planning a study (MTN-034/IPM 045) that will evaluate how adolescent girls and young women use the monthly dapivirine vaginal ring and Truvada as daily PrEP, and their preferences for either or both approaches.

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Unlike a Phase III clinical trial, there is no placebo group in an open-label study. In ASPIRE, there were 27 percent fewer women who acquired HIV in the group assigned to use the dapivirine ring than in the group who used a placebo ring with no active drug. The monthly ring tested in ASPIRE and The Ring Study, and offered to women in the HOPE and DREAM studies, contains an ARV drug, dapivirine, as a way to provide women potentially longer-acting protection against HIV. New results from exploratory analyses of data from ASPIRE reported today at The International Conference on AIDS (AIDS 2016) in Durban suggest even higher levels of protection can be achieved with regular and consistent use. It will be released June 2 at a Northwestern policy conference in Washington, D.C. MTN-034/IPM 045 will help to better understand the factors that may have contributed to the ring not being effective among those ages 18-21 in ASPIRE. Toward this end, MTN is planning a study (MTN-034/IPM 045) that will evaluate how adolescent girls and young women use the monthly dapivirine vaginal ring and Truvada as daily PrEP, and their preferences for either or both approaches.

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