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In another embodiment, the nucleotide sequence for the present disclosure is RNA. In some embodiments, the nucleotide sequence for the present methods is an oligomer. In some embodiments, the present method is utilized to select any therapeutic molecules comprising a nucleotide sequence (e.g., oligomers) that hybridize to a region within a MAPT transcript, e.g., SEQ ID NO: 2 (SEQ ID NO: 2 can be mRNA if "t" is replaced with "u"), a BASP1 transcript or an APP transcript. In one embodiment, random therapeutic molecules comprising nucleotide sequences (e.g., oligomers) targeting certain regions of pre-mRNA or mRNA encoding MAPT, BASP1, or watch Live Sexcam APP are prepared to test their toxicities. The therapeutic molecules comprising nucleotide sequences can then be subject to the methods of the present invention described elsewhere herein. Nucleotide sequences of any type can be analyzed using the methods of the current invention. In this regard, the nucleotide sequence of the invention can affect indirect inhibition of the protein through a reduction in mRNA levels, typically in a mammalian cell, such as a human cell, such as a neuronal cell. A "monoclonal antibody" is an antibody produced by a single clone of B lymphocytes or by a cell into which the light and heavy chain genes of a single antibody have been transfected.