J. Immunol. 187:1754. In some embodiments, variable regions described herein may be linked to Fc variants that enhance affinity for the inhibitory receptor Fc.gamma.RIIb, e.g., to enhance apoptosis-inducing or adjuvant activity. In one embodiment, the Fc variants provide selectively enhanced affinity to Fc.gamma.RIIb relative to one or more activating receptors. In certain embodiments, the antibodies described herein contain one or more glycosylation sites in either the light or heavy chain variable region. For example, in one embodiment, an IgG2 hinge variant comprises a wildtype IgG1 lower hinge. In some embodiments, the rigidity of the chimeric hinge is at least similar to that of a wildtype IgG2 hinge. TABLE-US-00007 TABLE 6 Additional Examples of "IgG2 Hinge" Human Heavy Chain Constant Regions SEQ ID Construct NO: Description G2-G1-G1-G1 120 CH1 domain of IgG2, with all else IgG1. In one embodiment, the two binding domain masks are linked to each other (but not the antibody) by a cleavable linker, for example, cleavable by a peptidase. Also provided herein are antibodies in which potential glycosylation sites within the antigen binding domain were eliminated to prevent glycosylation that may interfere with antigen binding. Accordingly, also provided herein are anti-ICOS antibodies that have one or more methionine residues in the heavy and/or light chain CDRs replaced with amino acid residues that do not undergo oxidative degradation.

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Исполнитель: VA
Название: Love Suggestions - If I Ain't Got You, Baby (2022)
Жанр: Jazz
Год выпуска: 2022
Количество треков: 18
Время звучания: 01:25:36
Формат: MP3
Качество: 320kbps
Размер: 197 MB

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